The title character Nathan Never is a special agent in a semi-dystopian near future where crime-fighting is shared between the police and corporate detective agencies such as Never's employer Agenzia Alfa.
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Stories typically merge classic urban crime, noir, and drama, with occasional forays into political thriller, survival horror, and space opera. Many issues quote classic science fiction film and literature, for example in names, locations, technology, etc. Primary sources of inspiration are Blade Runner and Isaac Asimov's Foundation series.